Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.51 |
| ▸ | BRD2 | P25440 | 11/20 | 0.51 |
| ▸ | BRD3 | Q15059 | 11/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319404 | 0.91 | BRD4 (0.47) | BRD4BRD2BRD3NPC1RAB9A | |
| SCHEMBL8319707 | 0.90 | HDAC3 (0.49) | BRD4BRD2BRD3HDAC3HDAC4 | |
| SCHEMBL8316386 | 0.89 | BRD4 (0.44) | BRD4BRD2BRD3PTGER4MEN1 | |
| SCHEMBL8318824 | 0.89 | BRD4 (0.45) | BRD4BRD2BRD3MEN1NPC1 | |
| SCHEMBL8320603 | 0.88 | BRD4 (0.48) | BRD4BRD2BRD3HDAC3HDAC4 | |
| SCHEMBL8317515 | 0.87 | BRD4 (0.43) | BRD4BRD2BRD3MEN1NPC1 | |
| SCHEMBL8316419 | 0.86 | BRD4 (0.42) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL8320796 | 0.84 | BRD4 (0.48) | BRD4BRD2BRD3HDAC3HDAC4 | |
| SCHEMBL8316020 | 0.84 | BRD4 (0.48) | BRD4BRD2BRD3HDAC3HDAC4 | |
| SCHEMBL8318078 | 0.81 | BRD4 (0.44) | BRD4BRD2BRD3MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |