Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311294 | 0.87 | APOBEC3G (0.42) | ADORA2AALDH1A1TP53KMT2ACDK9 | |
| SCHEMBL8316325 | 0.85 | CNR2 (0.39) | ADORA2AALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8313733 | 0.85 | ALDH1A1 (0.44) | ADORA2AALDH1A1TP53MAPTSMN1; SMN2 | |
| SCHEMBL13434139 | 0.72 | NPC1 (0.48) | ADORA2AALDH1A1TP53MAPTSMN1; SMN2 | |
| SCHEMBL8314234 | 0.70 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL8317607 | 0.69 | GAA (0.45) | ALDH1A1TP53MAPTSMN1; SMN2TSHR | |
| SCHEMBL8312922 | 0.68 | TLR8 (0.49) | ADORA2ATP53MAPTSMN1; SMN2MEN1 | |
| SCHEMBL8316328 | 0.68 | TLR8 (0.49) | ALDH1A1TP53MAPTSMN1; SMN2MEN1 | |
| SCHEMBL13434021 | 0.67 | MEN1 (0.47) | ALDH1A1TP53MAPTSMN1; SMN2MEN1 | |
| SCHEMBL10181870 | 0.65 | MAPT (0.75) | ALDH1A1TP53MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536419-B1 | TRICYCLIC TRIAZOLE DERIVATIVES, PRODUCTION AND USE THEREOF | TORAY INDUSTRIES (JP) | 1999-10-13 | — | — | EP | disclosed |
| EP-0536419-A1 | TRICYCLIC TRIAZOLE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1993-04-14 | — | — | EP | disclosed |