Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 3/20 | 0.51 |
| ▸ | FADS1 | O60427 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315938 | 0.94 | BRAF (0.58) | EGFRERBB2HPGDHTTCSNK2A2 | |
| SCHEMBL7142831 | 0.93 | EGFR (0.62) | EGFRERBB2HPGDHTTCSNK2A2 | |
| SCHEMBL8317294 | 0.88 | EGFR (0.58) | EGFRERBB2HPGDHTTCSNK2A2 | |
| SCHEMBL8316922 | 0.88 | EGFR (0.58) | EGFRERBB2HPGDHTTCSNK2A2 | |
| SCHEMBL8460531 | 0.88 | EGFR (0.58) | EGFRERBB2HPGDHTTCSNK2A2 | |
| SCHEMBL8317824 | 0.88 | EGFR (0.66) | EGFRERBB2HPGDHTT | |
| SCHEMBL8317377 | 0.88 | EGFR (0.58) | EGFRERBB2HPGDHTTCSNK2A2 | |
| SCHEMBL8316918 | 0.88 | EGFR (0.58) | EGFRERBB2HPGDHTTCSNK2A2 | |
| SCHEMBL8317381 | 0.88 | EGFR (0.58) | EGFRERBB2HPGDHTTCSNK2A2 | |
| SCHEMBL8317834 | 0.88 | EGFR (0.67) | EGFRERBB2HPGDHTTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |