SCHEMBL8317808

SCHEMBL8317808

CCOC(=O)c1cc([N+](=O)[O-])c[n+]([O-])c1C(=O)OCC

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.49
NPC1 O15118 1/20 0.48
MAPT P10636 6/20 0.46
POLB P06746 2/20 0.46
AR P10275 1/20 0.45
LMNA P02545 4/20 0.45
ALDH1A1 P00352 3/20 0.45
GALR2 O43603 1/20 0.45
MITF O75030 1/20 0.45
HSP90AA1 P07900 1/20 0.45
HPGD P15428 1/20 0.45
XBP1 P17861 1/20 0.45
CCR6 P51684 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
AKR1B1 P15121 1/20 0.43
KCNJ1 P48048 1/20 0.41
KCNH2 Q12809 1/20 0.41
CACNA1F O60840 1/20 0.41
ADORA3 P0DMS8 1/20 0.41
CACNA1D Q01668 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8659593 0.80 TSHR (0.46) NPC1MAPTPOLBLMNAALDH1A1
SCHEMBL7723906 0.76 SMN1; SMN2 (0.68) SMN1; SMN2NPC1MAPTARALDH1A1
SCHEMBL7116626 0.75 SMN1; SMN2 (0.64) SMN1; SMN2NPC1MAPTALDH1A1HPGD
SCHEMBL11514229 0.75 AKR1B1 (0.63) SMN1; SMN2NPC1MAPTPOLBLMNA
SCHEMBL550516 0.75 SMN1; SMN2 (0.63) SMN1; SMN2NPC1MAPTARALDH1A1
SCHEMBL4253497 0.74 MRGPRX4 (0.41) SMN1; SMN2NPC1MAPTALDH1A1HSP90AA1
SCHEMBL7017758 0.74 ALDH1A1 (0.51) SMN1; SMN2NPC1MAPTPOLBLMNA
SCHEMBL14114749 0.74 SMN1; SMN2 (0.61) SMN1; SMN2NPC1MAPTPOLBAR
SCHEMBL2616927 0.74 SMN1; SMN2 (0.61) SMN1; SMN2NPC1MAPTPOLBALDH1A1
SCHEMBL396778 0.74 NPC1 (0.54) SMN1; SMN2NPC1MAPTPOLBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5959116-A 5-NITRO PYRIDINE-2,3-DICARBOXYLIC ACID ESTER CHEMICAL INTERMEDIATES MADE BY REACTING THE N-OXIDES OF PYRIDINE-2,3-DICARBOXYLIC ACID ESTERS WITH NITRIC ACID OR SODIUM NITRATE, THEN REMOVING THE N-OXIDE GROUP BASF AKTIENGESELLSCHAFT (DE) 1999-09-28 US disclosed
US-5571774-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1996-11-05 US disclosed