Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318382 | 0.88 | EGFR (0.47) | EGFRABCG2DYRK1ADYRK1B | |
| SCHEMBL6996215 | 0.83 | ABCG2 (0.57) | EGFRABCG2 | |
| SCHEMBL8319085 | 0.83 | EGFR (0.44) | EGFRABCG2DYRK1ADYRK1B | |
| SCHEMBL8318294 | 0.79 | EGFR (0.46) | EGFRABCG2 | |
| SCHEMBL6995080 | 0.77 | BRAF (0.49) | — | |
| SCHEMBL10105955 | 0.76 | ALDH1A1 (0.46) | EGFR | |
| SCHEMBL6999651 | 0.76 | EGFR (0.46) | EGFRABCG2 | |
| SCHEMBL8318338 | 0.76 | EGFR (0.51) | EGFRDYRK1ADYRK1B | |
| SCHEMBL6991028 | 0.76 | GSK3A (0.55) | EGFRABCG2 | |
| SCHEMBL6991037 | 0.76 | GSK3A (0.55) | EGFRABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |