Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318233 | 0.88 | EGFR (0.47) | EGFRABCG2CA1CA2CA7 | |
| SCHEMBL6994362 | 0.84 | ABCG2 (0.56) | EGFRABCG2 | |
| SCHEMBL8317837 | 0.83 | EGFR (0.45) | EGFRABCG2DYRK1ADYRK1B | |
| SCHEMBL8314779 | 0.82 | EGFR (0.45) | EGFR | |
| SCHEMBL6997375 | 0.78 | EGFR (0.47) | EGFR | |
| SCHEMBL8317145 | 0.78 | EGFR (0.49) | EGFRDYRK1ADYRK1B | |
| SCHEMBL6991028 | 0.77 | GSK3A (0.55) | EGFRABCG2 | |
| SCHEMBL6991037 | 0.77 | GSK3A (0.55) | EGFRABCG2 | |
| SCHEMBL6995080 | 0.76 | BRAF (0.49) | — | |
| SCHEMBL6417047 | 0.76 | EGFR (0.66) | EGFRABCG2DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |