Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.44 |
| ▸ | BCL6 | P41182 | 2/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316240 | 0.93 | EGFR (0.69) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6999445 | 0.91 | EGFR (0.77) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8313702 | 0.88 | EGFR (0.64) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8314200 | 0.88 | EGFR (0.64) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8315348 | 0.88 | EGFR (0.64) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8315620 | 0.88 | EGFR (0.64) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8315344 | 0.88 | EGFR (0.64) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8313697 | 0.88 | EGFR (0.64) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8801513 | 0.87 | EGFR (0.62) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8317294 | 0.87 | EGFR (0.58) | EGFRERBB2HPGDHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |