Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD1 | Q13393 | 1/20 | 0.50 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6403047 | 1.00 | PLD1 (0.50) | PLD1CHI3L1GRM1GRIN2BGRIN2D | |
| SCHEMBL29505439 | 0.90 | GRM1 (0.49) | PLD1GRM1KDM4E | |
| SCHEMBL1245662 | 0.89 | PLD1 (0.58) | PLD1CHI3L1GPR119KDM4E | |
| Trifluoroacetic Acid SCHEMBL4749328 | 0.87 | DPP4 (0.60) | GRM1GPR119KDM4E | |
| SCHEMBL2294733 | 0.85 | GRIN2B (0.55) | PLD1GRM1GRIN2BGRIN2DGRIN3B | |
| SCHEMBL30937159 | 0.85 | GRIN2B (0.55) | PLD1GRM1GRIN2BGRIN2DGRIN3B | |
| SCHEMBL30146719 | 0.85 | PDE10A (0.41) | CHI3L1GRM1PDE10A | |
| SCHEMBL16474292 | 0.81 | PLD1 (0.51) | PLD1GRM1GRIN2BGRIN2DGRIN3B | |
| SCHEMBL23875675 | 0.79 | GRM1 (0.51) | PLD1GRM1GRIN2BGRIN2DGRIN3B | |
| SCHEMBL8091809 | 0.79 | GRM1 (0.51) | PLD1GRM1GRIN2BGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919782-A | CONTAINING A 2,4-DIOXOTRIAZOLIDINE RING | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1999-07-06 | — | — | US | disclosed |
| EP-0923580-A1 | THIAZOLIDINEDIONE COMPOUNDS HAVING ANTIDIABETIC, HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1999-06-23 | — | — | EP | disclosed |
| WO-1997041120-A1 | THIAZOLIDINEDIONE COMPOUNDS HAVING ANTIDIABETIC, HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-11-06 | — | — | WO | disclosed |