Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.60 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.60 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.60 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.60 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6403047 | 0.87 | PLD1 (0.50) | GPR119GRM1KDM4E | |
| SCHEMBL8318328 | 0.87 | PLD1 (0.50) | GPR119GRM1KDM4E | |
| Trifluoroacetic Acid SCHEMBL3904463 | 0.83 | DPP4 (0.61) | DPP4DPP8DPP9DPP7GPR119 | |
| Trifluoroacetic Acid SCHEMBL4748972 | 0.80 | NOTUM (0.55) | DPP4DPP8DPP9DPP7GPR119 | |
| Trifluoroacetic Acid SCHEMBL1024329 | 0.80 | ALDH1A1 (0.55) | DPP4DPP8DPP9DPP7GPR119 | |
| SCHEMBL29505439 | 0.79 | GRM1 (0.49) | GRM1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1245662 | 0.78 | PLD1 (0.58) | GPR119ALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL896038 | 0.78 | DPP4 (0.51) | DPP4DPP8DPP9DPP7GPR119 | |
| SCHEMBL4749329 | 0.77 | HRH3 (0.53) | DPP4DPP8DPP9DPP7GPR119 | |
| Trifluoroacetic Acid SCHEMBL22495370 | 0.76 | CHRNA7 (0.63) | DPP4DPP8DPP9DPP7GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008121065-A1 | NOVEL PYRROLIDINE DERIVATIVES AS ANTAGONISTS OF THE CHEMOKINE RECEPTOR | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | disclosed |