Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.53 |
| ▸ | MAOB | P27338 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 3/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27819611 | 0.90 | BRD4 (0.52) | MAOAMAOBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9688253 | 0.89 | MAOA (0.57) | MAOAMAOBSMN1; SMN2BAZ2BBRD4 | |
| SCHEMBL8319226 | 0.88 | BAZ2B (0.56) | MAOAMAOBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL29243215 | 0.87 | MAOA (0.55) | MAOAMAOBSMN1; SMN2BAZ2BBRD4 | |
| SCHEMBL8318498 | 0.85 | MAOA (0.51) | MAOAMAOBMAPTBAZ2BBRD4 | |
| SCHEMBL9403386 | 0.84 | MAOA (0.53) | MAOAMAOBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10631228 | 0.83 | MAOA (0.55) | MAOAMAOBALDH1A1BAZ2BBRD4 | |
| SCHEMBL3896033 | 0.82 | SMN1; SMN2 (0.55) | ALDH1A1MAPTSMN1; SMN2CA2CA5A | |
| SCHEMBL30957744 | 0.81 | MAOA (0.48) | MAOAMAOBMAPTSMN1; SMN2CA2 | |
| SCHEMBL19132364 | 0.81 | MAOA (0.50) | MAOAMAOBBRD4CYP2A6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929534-A1 | TRYCYCLIC COMPOUNDS AS PROSTAGLANDIN I2 RECEPTOR AGONISTS | Takeda Pharmaceutical Company Limited (JP) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013356-A1 | TRYCYCLIC COMPOUNDS AS PROSTAGLANDIN I2 RECEPTOR AGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-02 | — | — | WO | disclosed |
| EP-0333315-B1 | AZACYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | Dr. Lo. Zambeletti S.p.A. (IT) | 1991-06-12 | — | — | EP | disclosed |
| US-4994450-A | Side effect reduction | DR. LO. ZAMBELETTI S.P.A. (IT) | 1991-02-19 | — | — | US | disclosed |