Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.45 |
| ▸ | FAP | Q12884 | 1/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | LAP3 | P28838 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27804828 | 1.00 | DPP4 (0.45) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL5953881 | 0.79 | DPP4 (0.47) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL5953887 | 0.79 | DPP4 (0.47) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL3991048 | 0.75 | CYP2D6 (0.34) | — | |
| SCHEMBL8321404 | 0.71 | GRIK1 (0.38) | DPP4DPP8DPP9SLC7A5 | |
| SCHEMBL9651237 | 0.70 | — | — | |
| SCHEMBL6671727 | 0.70 | — | — | |
| SCHEMBL2512216 | 0.70 | — | — | |
| SCHEMBL271971 | 0.70 | — | — | |
| SCHEMBL892804 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3636263-B1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL | ALLERGAN INC (US) | 2021-11-03 | — | — | EP | claimed |
| EP-3636263-A1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL | ALLERGAN, INC. (US) | 2020-04-15 | — | — | EP | claimed |
| EP-3050564-B1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL | ALLERGAN INC (US) | 2019-09-04 | — | — | EP | claimed |
| EP-3050564-A1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL | ALLERGAN, INC. (US) | 2016-08-03 | — | — | EP | claimed |
| EP-3636263-B1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL | ALLERGAN INC (US) | 2021-11-03 | — | — | EP | disclosed |
| EP-3050564-B1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL | ALLERGAN INC (US) | 2019-09-04 | — | — | EP | disclosed |
| US-5994342-A | 3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives useful as antitumor agents | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1999-11-30 | — | — | US | disclosed |
| EP-0688324-A1 | NOVEL 3-(SUBSTITUTED METHYL)-4-OXA-1-AZABICYCLO 3.2.0]HEPTAN-7-ONE DERIVATIVES USEFUL AS ANTITUMOR AGENTS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1995-12-27 | — | — | EP | disclosed |
| WO-1995018807-A1 | NOVEL 3-(SUBSTITUTED METHYL)-4-OXA-1-AZABICYCLO[3.2.0]HEPTAN-7-ONE DERIVATIVES USEFUL AS ANTITUMOR AGENTS | TAIHO PHARMACEUTICAL CO. LIMITED (JP) | 1995-07-13 | — | — | WO | disclosed |