Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319779 | 1.00 | MAPT (0.46) | MAPTALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL8300965 | 0.84 | POLB (0.41) | MAPTALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL5313843 | 0.76 | KDM4E (0.42) | MAPTALDH1A1TDP1KMT2AL3MBTL1 | |
| SCHEMBL2388710 | 0.71 | TSHR (0.50) | ALDH1A1POLBCYP2C9TDP1KMT2A | |
| SCHEMBL16975425 | 0.69 | MAPT (0.50) | MAPTALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL11109939 | 0.69 | MAPT (0.71) | MAPTALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL16975422 | 0.69 | MAPT (0.50) | MAPTALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL15709280 | 0.69 | MAPT (0.71) | MAPTALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL11109921 | 0.69 | MAPT (0.71) | MAPTALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL17847031 | 0.68 | MAPT (0.53) | MAPTALDH1A1POLBCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938474-A2 | CYCLOPROPYLINDOLE COMPOUNDS AND THEIR USE AS PRODRUGS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998011101-A2 | CONDENSED N-ACLYINDOLES AS ANTITUMOR AGENTS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1998-03-19 | — | — | WO | disclosed |