Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TPMT | P51580 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 2/20 | 0.38 |
| ▸ | DNA2 | P51530 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701010 | 0.85 | POLB (0.42) | TSHRPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL7811994 | 0.85 | POLB (0.42) | TSHRPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL8963317 | 0.84 | KDM4E (0.40) | TSHRPOLBMEN1ALDH1A1PKM | |
| SCHEMBL19332726 | 0.84 | CCNC (0.44) | TSHRALDH1A1TDP1L3MBTL1KDM4E | |
| SCHEMBL4703943 | 0.81 | KMT2A (0.43) | TSHRMEN1ALDH1A1KMT2ATDP1 | |
| SCHEMBL7056735 | 0.78 | HPGD (0.45) | POLBMEN1ALDH1A1PKMKMT2A | |
| SCHEMBL23348176 | 0.74 | TPMT (0.39) | TSHRTDP1L3MBTL1FBP1CYP1A2 | |
| SCHEMBL18040270 | 0.73 | POLB (0.49) | POLBMEN1ALDH1A1PKMNPY1R | |
| SCHEMBL8319779 | 0.71 | MAPT (0.46) | TSHRPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL8319090 | 0.71 | MAPT (0.46) | TSHRPOLBMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840529-B2 | Substituted pyrimidines as LRKK2 inhibitors | DENALI THERAPEUTICS INC. (US) | 2023-12-12 | — | — | US | disclosed |
| US-20210300914-A1 | SUBSTITUTED PYRIMIDINES AS LRKK2 INHIBITORS | DENALI THERAPEUTICS INC. (US) | 2021-09-30 | — | — | US | disclosed |
| US-11028080-B2 | Substituted pyrimidines as LRKK2 inhibitors | DENALI THERAPEUTICS INC. (US) | 2021-06-08 | — | — | US | disclosed |
| US-20190084975-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. | 2019-03-21 | — | — | US | disclosed |
| EP-3350145-A1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | Board of Regents, The University of Texas System (US) | 2018-07-25 | — | — | EP | disclosed |
| WO-2017156493-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-09-14 | — | — | WO | disclosed |
| WO-2017049091-A1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-03-23 | — | — | WO | disclosed |
| US-8017599-B2 | Sequence selective pyrrole and imidazole polyamide metallocomplexes | UNIVERSITY OF WESTERN SYDNEY (AU) | 2011-09-13 | — | — | US | disclosed |
| EP-1678133-A4 | SEQUENCE SELECTIVE PYRROLE AND IMIDAZOLE POLYAMIDE METALLOCOMPLEXES | UNIV WESTERN SYDNEY (AU) | 2008-06-18 | — | — | EP | disclosed |
| US-20070265240-A1 | Sequence Selective Pyrrole and Imidazole Polyamide Metallocomplexes | UNIVERSITY OF WESTERN SYDNEY (AU) | 2007-11-15 | — | — | US | disclosed |
| EP-0991417-A1 | COMPLEX FORMATION BETWEEN DSDNA AND OLIGOMER OF HETEROCYCLES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0986539-A1 | DNA-BINDING PYRROLE AND IMIDAZOLE POLYAMIDE DERIVATIVES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2000-03-22 | — | — | EP | disclosed |
| US-5998140-A | COMPLEXES OF CELL WITH OLIGOMER | THE SCRIPPS RESEARCH INSTITUTE (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0885189-A2 | METHOD FOR THE SYNTHESIS OF POLY-PYRROLE AND POLY-IMIDAZOLE CARBOXAMIDES ON A SOLID SUPPORT | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1998050582-A1 | COMPLEX FORMATION BETWEEN dsDNA AND OLIGOMER OF HETEROCYCLES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1998-11-12 | — | — | WO | disclosed |
| WO-1998050058-A1 | COMPLEX FORMATION BETWEEN DSDNA AND OLIGOMER OF HETEROCYCLES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1998-11-12 | — | — | WO | disclosed |
| WO-1998049142-A1 | DNA-BINDING PYRROLE AND IMIDAZOLE POLYAMIDE DERIVATIVES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1998-11-05 | — | — | WO | disclosed |
| WO-1997030975-A2 | METHOD FOR THE SYNTHESIS OF POLY-PYRROLE AND POLY-IMIDAZOLE CARBOXAMIDES ON A SOLID SUPPORT | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1997-08-28 | — | — | WO | disclosed |
| EP-0722446-A1 | DISTAMYCIN A ANALOGUES AS ANTITUMOUR OR ANTIVIRAL AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-07-24 | — | — | EP | disclosed |
| WO-1996005196-A1 | DISTAMYCIN A ANALOGUES AS ANTITUMOUR OR ANTIVIRAL AGENTS | PHARMACIA S.P.A. (IT) | 1996-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11028080-B2 | Substituted pyrimidines as LRKK2 inhibitors | LRRK2, DTYMK, LMTK2 | TSHR 3907/4885POLB 1012/4885MEN1 2687/4885 |
| US-11840529-B2 | Substituted pyrimidines as LRKK2 inhibitors | LRRK2, DTYMK, LMTK2 | TSHR 3907/4885POLB 1012/4885MEN1 2687/4885 |
| US-20210300914-A1 | SUBSTITUTED PYRIMIDINES AS LRKK2 INHIBITORS | LRRK2, DTYMK, LMTK2 | TSHR 3907/4885POLB 1012/4885MEN1 2687/4885 |
| US-20190084975-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | LRRK2, SNCA, PARK7 | TSHR 3899/4885POLB 1026/4885MEN1 907/4885 |
| US-20070265240-A1 | Sequence Selective Pyrrole and Imidazole Polyamide Metallocomplexes | POLRMT, MPI, PPIF | TSHR 2789/4885POLB 64/4885MEN1 563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.