Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | ELANE | P08246 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323888 | 0.97 | KMT2A (0.49) | KMT2AMEN1CYP3A4CYP2C9ELANE | |
| SCHEMBL8192331 | 0.86 | MEN1 (0.53) | KMT2AMEN1CYP3A4CYP2C9ELANE | |
| SCHEMBL8323187 | 0.84 | MEN1 (0.54) | KMT2AMEN1CYP3A4CYP2C9ELANE | |
| SCHEMBL8318729 | 0.80 | GAA (0.44) | KMT2AMEN1CYP3A4CYP2C9CA1 | |
| SCHEMBL8321322 | 0.73 | KMT2A (0.39) | KMT2AMEN1CYP3A4CYP2C9LMNA | |
| SCHEMBL11724369 | 0.72 | MAPT (0.55) | KMT2AMEN1CYP3A4CYP2C9LMNA | |
| SCHEMBL5233956 | 0.72 | KMT2A (0.58) | KMT2AMEN1CYP3A4CYP2C9ELANE | |
| SCHEMBL11686018 | 0.71 | KMT2A (0.56) | KMT2AMEN1CYP3A4CYP2C9ELANE | |
| SCHEMBL10652678 | 0.71 | CYP1A2 (0.49) | KMT2AMEN1CYP3A4CYP2C9LMNA | |
| SCHEMBL10652165 | 0.70 | CYP1A2 (0.48) | KMT2AMEN1CYP3A4CYP2C9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717043-B1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1999-11-10 | — | — | EP | claimed |
| EP-0717043-A1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1996-06-19 | — | — | EP | claimed |
| EP-0717043-B1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1999-11-10 | — | — | EP | disclosed |
| EP-0924211-A2 | 1,2 bridged 1,4-dihydropyridines as selective potassium channel modulators | Bayer Aktiengesellschaft (DE) | 1999-06-23 | — | — | EP | disclosed |
| EP-0717043-A1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1996-06-19 | — | — | EP | disclosed |