Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317255 | 0.97 | GAA (0.45) | GAAPOLBWDR5MEN1KMT2A | |
| SCHEMBL8318029 | 0.84 | ALDH1A1 (0.46) | GAAMEN1KMT2ACASP1ALDH1A1 | |
| SCHEMBL8319747 | 0.84 | POLB (0.46) | GAAPOLBWDR5MEN1KMT2A | |
| SCHEMBL8319383 | 0.83 | HPGD (0.43) | GAAPOLBCASP1ALDH1A1HTT | |
| SCHEMBL8320521 | 0.82 | KMT2A (0.38) | GAAPOLBWDR5MEN1KMT2A | |
| SCHEMBL8319794 | 0.81 | POLB (0.47) | GAAPOLBWDR5MEN1KMT2A | |
| SCHEMBL8468645 | 0.80 | HPGD (0.43) | GAAPOLBCASP1ALDH1A1HTT | |
| SCHEMBL8319136 | 0.80 | KMT2A (0.48) | POLBMEN1KMT2AMAPTCA1 | |
| SCHEMBL8321322 | 0.79 | KMT2A (0.39) | GAAPOLBWDR5MEN1KMT2A | |
| SCHEMBL8321061 | 0.77 | HPGD (0.41) | GAAPOLBCASP1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717043-B1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1999-11-10 | — | — | EP | claimed |
| EP-0717043-A1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1996-06-19 | — | — | EP | claimed |