Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.53 |
| ▸ | ELANE | P08246 | 3/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192331 | 0.97 | MEN1 (0.53) | MEN1KMT2ACYP3A4CYP2C9ELANE | |
| SCHEMBL8323888 | 0.86 | KMT2A (0.49) | MEN1KMT2ACYP3A4CYP2C9ELANE | |
| SCHEMBL8319136 | 0.84 | KMT2A (0.48) | MEN1KMT2ACYP3A4CYP2C9ELANE | |
| SCHEMBL11724369 | 0.81 | MAPT (0.55) | MEN1KMT2ACYP3A4CYP2C9HIF1A | |
| SCHEMBL11729475 | 0.80 | CYP1A2 (0.66) | MEN1KMT2ACYP3A4CYP2C9HIF1A | |
| SCHEMBL8319794 | 0.78 | POLB (0.47) | MEN1KMT2ACYP3A4CYP2C9ELANE | |
| SCHEMBL11725221 | 0.76 | CYP1A2 (0.64) | MEN1KMT2ACYP3A4CYP2C9HIF1A | |
| SCHEMBL11727265 | 0.76 | CYP1A2 (0.64) | MEN1KMT2ACYP3A4CYP2C9HIF1A | |
| SCHEMBL8319747 | 0.75 | POLB (0.46) | MEN1KMT2ACYP3A4CYP2C9CYP1A2 | |
| SCHEMBL5233956 | 0.75 | KMT2A (0.58) | MEN1KMT2ACYP3A4CYP2C9ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717043-B1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1999-11-10 | — | — | EP | claimed |