Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.58 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 3/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8269327 | 1.00 | PARP1 (0.58) | PARP1PRSS1PRSS2PRSS3PDE4A | |
| SCHEMBL4816445 | 0.84 | PDE4A (0.56) | PARP1PRSS1PRSS2PRSS3PDE4A | |
| SCHEMBL8269336 | 0.83 | PARP1 (0.66) | PARP1PRSS1PRSS2PRSS3PDE4A | |
| SCHEMBL17122434 | 0.81 | PARP1 (0.57) | PARP1PRSS1PRSS2PRSS3PDE4A | |
| SCHEMBL10897886 | 0.75 | CES2 (0.67) | PARP1PRSS1PRSS2PRSS3PDE4A | |
| SCHEMBL29503138 | 0.74 | PARP1 (1.00) | PARP1PRSS1PRSS2PRSS3CES2 | |
| SCHEMBL283787 | 0.74 | PARP1 (1.00) | PARP1PRSS1PRSS2PRSS3CES2 | |
| Hydrochloric Acid SCHEMBL407554 | 0.73 | PARP1 (0.96) | PARP1PRSS1PRSS2PRSS3CES2 | |
| SCHEMBL4820908 | 0.73 | CES2 (0.69) | PARP1PRSS1PRSS2PRSS3PDE4A | |
| Hydrochloric Acid SCHEMBL4377519 | 0.73 | PARP1 (0.96) | PARP1PRSS1PRSS2PRSS3CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004078144-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2004-09-16 | — | — | WO | disclosed |