Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 10/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323430 | 0.92 | KDM4E (0.42) | KDM4EMEN1GAATSHRHTT | |
| SCHEMBL9067611 | 0.80 | TP53 (0.43) | DHFRSLC2A1CSNK1A1CLK4 | |
| SCHEMBL4222830 | 0.78 | DHFR (0.47) | DHFRSLC2A1CSNK1A1CLK4 | |
| SCHEMBL8322368 | 0.76 | DHFR (0.46) | DHFRSLC2A1 | |
| SCHEMBL8468661 | 0.76 | DHFR (0.43) | DHFRSLC2A1 | |
| SCHEMBL8324477 | 0.75 | DHFR (0.41) | DHFRSLC2A1 | |
| SCHEMBL8320187 | 0.73 | MAPK1 (0.42) | KDM4EMEN1GAATSHRHTT | |
| SCHEMBL20641250 | 0.68 | CSNK1A1 (0.51) | KDM4EMEN1GAATSHRHTT | |
| SCHEMBL20641252 | 0.68 | HSP90AA1 (0.47) | KDM4EMEN1GAATSHRHTT | |
| SCHEMBL26324937 | 0.67 | KDM5A (0.43) | KDM4EMEN1GAATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638079-B1 | DEAZAAMINOPTERINS FOR TREATMENT OF INFLAMMATION | STANFORD RES INST INT (US) | 1999-12-15 | — | — | EP | disclosed |
| US-5536724-A | Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins | SRI INTERNATIONAL (US) | 1996-07-16 | — | — | US | disclosed |
| EP-0638079-A1 | DEAZAAMINOPTERINS FOR TREATMENT OF INFLAMMATION | SRI INTERNATIONAL (US) | 1995-02-15 | — | — | EP | disclosed |
| WO-1993022312-A1 | DEAZAAMINOPTERINS FOR TREATMENT OF INFLAMMATION | SRI INTERNATIONAL (US) | 1993-11-11 | — | — | WO | disclosed |