Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | USP7 | Q93009 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321298 | 0.90 | KDM4E (0.45) | MAPK1RECQLKMT2AMEN1KDM4E | |
| SCHEMBL28289900 | 0.86 | USP7 (0.41) | MAPK1RECQLKMT2AMEN1KDM4E | |
| SCHEMBL9068427 | 0.75 | TP53 (0.46) | MAPK1KMT2AMEN1KDM4ETSHR | |
| SCHEMBL5200520 | 0.75 | USP7 (0.43) | MAPK1KMT2AMEN1KDM4ETSHR | |
| SCHEMBL26324937 | 0.73 | KDM5A (0.43) | MAPK1RECQLKMT2AMEN1KDM4E | |
| SCHEMBL8319699 | 0.73 | KDM4E (0.39) | KMT2AMEN1KDM4ETSHRHSD17B10 | |
| SCHEMBL10690802 | 0.73 | KDM4E (0.44) | KMT2AMEN1KDM4ETSHRHSD17B10 | |
| SCHEMBL26343118 | 0.72 | KDM5A (0.44) | MAPK1KMT2AMEN1KDM4ETSHR | |
| SCHEMBL27883134 | 0.72 | CSNK1A1 (0.47) | MAPK1RECQLKDM4EGAAHTT | |
| SCHEMBL20641250 | 0.71 | CSNK1A1 (0.51) | MAPK1RECQLKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638079-B1 | DEAZAAMINOPTERINS FOR TREATMENT OF INFLAMMATION | STANFORD RES INST INT (US) | 1999-12-15 | — | — | EP | disclosed |
| EP-0638079-A1 | DEAZAAMINOPTERINS FOR TREATMENT OF INFLAMMATION | SRI INTERNATIONAL (US) | 1995-02-15 | — | — | EP | disclosed |
| WO-1993022312-A1 | DEAZAAMINOPTERINS FOR TREATMENT OF INFLAMMATION | SRI INTERNATIONAL (US) | 1993-11-11 | — | — | WO | disclosed |