Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 7/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18542949 | 0.86 | ALDH1A1 (0.70) | HPGDALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL14045083 | 0.84 | ALDH1A1 (0.56) | HPGDALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10546402 | 0.84 | HPGD (0.70) | HPGDALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL11704529 | 0.84 | HPGD (0.74) | HPGDALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL28879832 | 0.83 | ALDH1A1 (0.80) | HPGDALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5495002 | 0.81 | HPGD (0.66) | HPGDALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL23879885 | 0.81 | HPGD (0.66) | HPGDALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL18542950 | 0.81 | HPGD (0.66) | HPGDALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL24646014 | 0.81 | HPGD (0.66) | HPGDALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL11627330 | 0.81 | HPGD (0.70) | HPGDALDH1A1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592684-B1 | MALONAMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-07-30 | — | — | EP | disclosed |
| US-7375099-B2 | secretase inhibitors; therapy for Alzheimer's disease | HOFFMANN-LA ROCHE INC. (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375099-B2 | secretase inhibitors; therapy for Alzheimer's disease | HOFFMANN-LA ROCHE INC. (US) | 2008-05-20 | — | — | US | disclosed |
| WO-2004069826-A1 | MALONAMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-19 | — | — | WO | disclosed |