Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 7/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | GAPDH | P04406 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171960 | 0.83 | ALDH1A1 (0.56) | HPGDALDH1A1POLBRAB9AMEN1 | |
| SCHEMBL10344961 | 0.82 | HPGD (0.68) | HPGDALDH1A1POLBRAB9AMEN1 | |
| SCHEMBL8319802 | 0.81 | HPGD (0.72) | HPGDALDH1A1POLBRAB9AMEN1 | |
| SCHEMBL2561707 | 0.81 | POLB (0.54) | HPGDALDH1A1POLBRAB9AMEN1 | |
| SCHEMBL8316469 | 0.81 | HPGD (0.66) | HPGDALDH1A1POLBRAB9AMEN1 | |
| SCHEMBL965878 | 0.81 | HPGD (0.66) | HPGDALDH1A1POLBRAB9AMEN1 | |
| SCHEMBL11585107 | 0.81 | HPGD (0.66) | HPGDALDH1A1POLBRAB9AMEN1 | |
| SCHEMBL12264637 | 0.81 | HPGD (0.66) | HPGDALDH1A1POLBRAB9AMEN1 | |
| SCHEMBL9185531 | 0.81 | HPGD (0.66) | HPGDALDH1A1POLBRAB9AMEN1 | |
| SCHEMBL10345060 | 0.80 | HPGD (0.60) | HPGDALDH1A1POLBRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11795491-B2 | Photoactivatable antimicrobial agents and therapeutic and diagnostic methods of using same | THE GENERAL HOSPITAL CORPORATION (US) | 2023-10-24 | — | — | US | disclosed |
| WO-2021105512-A1 | FLUOROGENIC BETA-LACTAMASE SUBSTRATE AND ASSOCIATED DETECTION METHOD | MOLSID (FR) | 2021-06-03 | — | — | WO | disclosed |
| US-10874107-B2 | β-lactamase targeted photosensitizer for pesticide and pest detection | THE GENERAL HOSPITAL CORPORATION (US) | 2020-12-29 | — | — | US | disclosed |
| US-20200154710-A1 | BETA-LACTAMASE TARGETED PHOTOSENSITIZER FOR PESTICIDE AND PEST DETECTION | BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT | 2020-05-21 | — | — | US | disclosed |
| US-10172874-B2 | Pharmaceutical compositions comprising cyclic boronic acid ester derivatives | REMPEX PHARMACEUTICALS, INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180207183-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES | MELINTA SUBSIDIARY CORP. | 2018-07-26 | — | — | US | disclosed |
| US-20180094292-A1 | Photoactivatable Antimicrobial Agents And Therapeutic And Diagnostic Methods Of Using Same | THE GENERAL HOSPITAL CORPORATION | 2018-04-05 | — | — | US | disclosed |
| US-9828622-B2 | Photoactivatable antimicrobial agents and therapeutic and diagnostic methods of using same | THE GENERAL HOSPITAL CORPORATION (US) | 2017-11-28 | — | — | US | disclosed |
| US-9828622-B2 | Photoactivatable antimicrobial agents and therapeutic and diagnostic methods of using same | THE GENERAL HOSPITAL CORPORATION (US) | 2017-11-28 | — | — | US | disclosed |
| US-9493444-B2 | Azaheterocyclic compounds | MERCK PATENT GMBH (DE) | 2016-11-15 | — | — | US | disclosed |
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0191163-B1 | PROCESS FOR THE PRODUCTION OF THIOLHYDROXAMATES | MAKHTESHIM CHEMICAL WORKS LIMITED (IL) | 1990-05-23 | — | — | EP | disclosed |
| EP-0093376-B1 | 1-SULFO-2-AZETIDINONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-03-21 | — | — | EP | disclosed |
| US-4822788-A | MICROBIOCIDES, BETA-LACTAMASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| US-4822790-A | ANTIMICROBIOCIDES OR BETA-LACTAMASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| US-4782147-A | ANTIBIOTIC | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-11-01 | — | — | US | disclosed |
| US-4675397-A | MICROBIOCIDES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-06-23 | — | — | US | disclosed |
| US-4665067-A | BACTERICIDES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-05-12 | — | — | US | disclosed |
| US-4550105-A | BETA-LACTAMASE INHIBITORS, ANTIBIOTICS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1985-10-29 | — | — | US | disclosed |
| EP-0093376-A2 | 1-Sulfo-2-azetidinone derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1983-11-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180207183-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES | BCL6B, SLC10A2, ABCB11 | HPGD 1334/4885ALDH1A1 3286/4885POLB 1208/4885 |
| US-10874107-B2 | β-lactamase targeted photosensitizer for pesticide and pest detection | DDT, BCHE, GUSB | HPGD 858/4885ALDH1A1 500/4885POLB 1455/4885 |
| US-20180094292-A1 | Photoactivatable Antimicrobial Agents And Therapeutic And Diagnostic Methods Of Using Same | HMBS, GUSB, LCT | HPGD 477/4885ALDH1A1 139/4885POLB 129/4885 |
| US-11795491-B2 | Photoactivatable antimicrobial agents and therapeutic and diagnostic methods of using same | HMBS, GUSB, LCT | HPGD 477/4885ALDH1A1 139/4885POLB 129/4885 |
| US-10172874-B2 | Pharmaceutical compositions comprising cyclic boronic acid ester derivatives | BCL6B, SLC10A2, ABCB11 | HPGD 1334/4885ALDH1A1 3286/4885POLB 1208/4885 |
| US-20200154710-A1 | BETA-LACTAMASE TARGETED PHOTOSENSITIZER FOR PESTICIDE AND PEST DETECTION | DDT, BCHE, GUSB | HPGD 782/4885ALDH1A1 479/4885POLB 1217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.