Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 8/20 | 0.35 |
| ▸ | BRD2 | P25440 | 7/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 7/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.35 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320759 | 0.89 | BRD4 (0.42) | BRS3BRD4BRD2BRD3 | |
| SCHEMBL8314769 | 0.86 | BRD4 (0.46) | CYP11B1CYP11B2BRD4BRD2BRD3 | |
| SCHEMBL8318636 | 0.82 | BRD4 (0.47) | CYP11B1CYP11B2BRD4BRD2BRD3 | |
| SCHEMBL8319774 | 0.81 | AR (0.41) | CYP11B1CYP11B2BRD4BRD2BRD3 | |
| SCHEMBL8321315 | 0.81 | BRD4 (0.39) | CYP11B1CYP11B2BRD4BRD2BRD3 | |
| Hydrochloric Acid SCHEMBL8319535 | 0.80 | BRD4 (0.38) | CYP11B1CYP11B2BRD4BRD2BRD3 | |
| SCHEMBL8317338 | 0.78 | HDAC3 (0.40) | BRD4BRD2BRD3 | |
| SCHEMBL8321540 | 0.77 | BRD4 (0.43) | CYP11B1CYP11B2BRD4BRD2BRD3 | |
| SCHEMBL8322984 | 0.73 | BRD4 (0.51) | BRD4BRD2BRD3 | |
| SCHEMBL8316889 | 0.73 | BRD4 (0.46) | BRD4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | claimed |
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |