Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322800 | 0.90 | MGLL (0.41) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL8320255 | 0.78 | HDAC8 (0.40) | ALDH1A1KDM4EMAPK1SMN1; SMN2HDAC1 | |
| SCHEMBL8319501 | 0.77 | THRB (0.54) | ALDH1A1KDM4ESMN1; SMN2HDAC1HDAC3 | |
| SCHEMBL8323882 | 0.77 | HDAC1 (0.39) | ALDH1A1KDM4EMAPK1SMN1; SMN2TRPM8 | |
| SCHEMBL8323566 | 0.76 | MAPT (0.35) | ALDH1A1MAPK1SMN1; SMN2HDAC1HDAC3 | |
| SCHEMBL8322776 | 0.76 | MGLL (0.40) | ALDH1A1SMN1; SMN2HDAC1HDAC3HDAC2 | |
| SCHEMBL8320188 | 0.76 | HDAC1 (0.46) | KDM4ETRPM8HDAC1HDAC3HDAC2 | |
| SCHEMBL17434586 | 0.76 | HDAC3 (0.67) | ALDH1A1KDM4EMAPK1SMN1; SMN2TRPM8 | |
| SCHEMBL8318949 | 0.76 | HDAC8 (0.37) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL8327938 | 0.75 | HDAC1 (0.39) | ALDH1A1SMN1; SMN2HDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |