Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.78 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.46 |
| ▸ | CLK1 | P49759 | 2/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL720820 | 0.87 | MAP3K11 (1.00) | MAP3K11MAPK8MAPK9MAPK10TDO2 | |
| SCHEMBL1487612 | 0.84 | MAPK8 (0.67) | MAP3K11MAPK8MAPK9MAPK10BRD4 | |
| SCHEMBL8313453 | 0.81 | MAP3K11 (0.81) | MAP3K11MAPK8MAPK9MAPK10TDO2 | |
| SCHEMBL15779335 | 0.78 | MAP3K11 (0.62) | MAP3K11BRD4TDO2DYRK1AKIT | |
| SCHEMBL720833 | 0.77 | MAP3K11 (0.74) | MAP3K11MAPK8MAPK9MAPK10TDO2 | |
| SCHEMBL721195 | 0.77 | MAP3K11 (1.00) | MAP3K11MAPK8MAPK9MAPK10DYRK1A | |
| SCHEMBL20408723 | 0.77 | KIT (0.59) | BRD4DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL12829259 | 0.77 | NTRK1 (0.66) | MAP3K11BRD4DYRK1ACLK1DYRK2 | |
| SCHEMBL8320542 | 0.77 | DYRK1A (0.59) | MAP3K11BRD4DYRK1ACLK1DYRK2 | |
| SCHEMBL1800807 | 0.76 | AXL (0.73) | MAP3K11AXLCDK8TNIKNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| WO-2004078756-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | MAPKAPK2, MAPK1, MAPKAPK3 | MAP3K11 23/4885MAPK8 50/4885MAPK9 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.