Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.64 |
| ▸ | DRD4 | P21917 | 6/20 | 0.55 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320213 | 0.84 | FAAH (0.60) | DRD4DRD3DRD2 | |
| SCHEMBL27317684 | 0.83 | CHKA (0.78) | CHKAKCNH2SMN1; SMN2KMT2AMET | |
| SCHEMBL31428708 | 0.82 | CHKA (0.64) | CHKASMN1; SMN2METTSHR | |
| SCHEMBL13499600 | 0.82 | CHKA (0.90) | CHKAADRA2AADRA2BADRA2CKCNH2 | |
| SCHEMBL11830305 | 0.82 | KMT2A (0.76) | CHKADRD4DRD3DRD2KMT2A | |
| SCHEMBL14604923 | 0.80 | CHKA (0.64) | CHKASMN1; SMN2METGNRHRSIGMAR1 | |
| SCHEMBL10482671 | 0.79 | DRD4 (0.55) | DRD4DRD3HTR1AALDH1A1SMN1; SMN2 | |
| SCHEMBL31429049 | 0.77 | CHKA (0.65) | CHKAKCNH2LMNASMN1; SMN2KMT2A | |
| SCHEMBL9590379 | 0.77 | CHKA (0.62) | CHKAADRA2AADRA2BADRA2CKCNH2 | |
| SCHEMBL9826322 | 0.77 | DRD3 (0.76) | DRD3HTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5945421-A | TREATING PSYCHOSIS AND SCHIZOPHRENIA | WARNER-LAMBERT COMPANY (US) | 1999-08-31 | — | — | US | disclosed |