Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | FNTA | P49354 | 1/20 | 0.48 |
| ▸ | FNTB | P49356 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 5/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6781672 | 0.84 | PTAFR (0.52) | PTAFRMEN1KMT2AFNTAFNTB | |
| SCHEMBL6779286 | 0.84 | PTAFR (0.52) | PTAFRMEN1KMT2AFNTAFNTB | |
| SCHEMBL6785728 | 0.83 | PTAFR (0.53) | PTAFRMEN1KMT2AFNTAFNTB | |
| Cycliramine SCHEMBL2109915 | 0.76 | MEN1 (0.82) | PTAFRMEN1KMT2AFNTAFNTB | |
| SCHEMBL16840345 | 0.76 | KCNH2 (0.44) | PTAFRMEN1KMT2AFNTAFNTB | |
| SCHEMBL8311278 | 0.74 | MEN1 (0.53) | PTAFRMEN1KMT2AFNTAFNTB | |
| Cycliramine SCHEMBL634920 | 0.69 | MEN1 (1.00) | PTAFRMEN1KMT2AFNTAFNTB | |
| SCHEMBL8316876 | 0.68 | OPRD1 (0.53) | PTAFRMEN1KMT2AOPRD1OPRM1 | |
| SCHEMBL12781730 | 0.68 | PTAFR (0.58) | PTAFRMEN1KMT2AFNTAFNTB | |
| SCHEMBL6583543 | 0.67 | OPRD1 (0.62) | PTAFRMEN1KMT2AFNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004066960-A2 | COMBINATION OF H1, H3 AND H4 RECEPTOR ANTAGONISTS FOR TREATMENT OF ALLERGIC AND NON-ALLERGIC PULMONARY INFLAMMATION, CONGESTION AND ALLERGIC RHINITIS | SCHERING CORPORATION (US) | 2004-08-12 | — | — | WO | disclosed |