Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 13/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | CCKBR | P32239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318668 | 0.81 | BRD4 (0.59) | BRD4LMNAGABRA1HPGDCNR1 | |
| SCHEMBL9886480 | 0.75 | BRD4 (0.41) | BRD4AKT1NPC1RAB9AKMT2A | |
| SCHEMBL8317643 | 0.75 | BRD4 (0.43) | BRD4KMT2ALMNAGABRA1HPGD | |
| SCHEMBL21847194 | 0.75 | BRD4 (0.39) | BRD4LMNAGABRA1HPGDCNR1 | |
| SCHEMBL17479961 | 0.74 | BRD4 (0.42) | BRD4AKT1NPC1RAB9AKMT2A | |
| SCHEMBL8316669 | 0.72 | OPRK1 (0.61) | BRD4LMNAGABRA1HPGDCNR1 | |
| Bromide SCHEMBL8319843 | 0.71 | OPRK1 (0.60) | BRD4LMNAGABRA1HPGDCNR1 | |
| SCHEMBL8319224 | 0.71 | BRD4 (0.46) | BRD4AKT1BRD2BRD3 | |
| SCHEMBL8317008 | 0.70 | OPRK1 (0.48) | BRD4OPRK1BRD2BRD3 | |
| SCHEMBL8323556 | 0.70 | BRD4 (0.54) | BRD4LMNAGABRA1HPGDCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |