Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 7/20 | 0.61 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.61 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.61 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.61 |
| ▸ | BRD4 | O60885 | 4/20 | 0.61 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | CNR1 | P21554 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8319843 | 0.99 | OPRK1 (0.60) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL8318693 | 0.87 | GABRA1 (0.61) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11107514 | 0.85 | GABRA1 (0.61) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11103275 | 0.85 | PTAFR (0.47) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL8318668 | 0.85 | BRD4 (0.59) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL8323556 | 0.84 | BRD4 (0.54) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL8319825 | 0.80 | BRD4 (0.44) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL8317643 | 0.78 | BRD4 (0.43) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL8319224 | 0.77 | BRD4 (0.46) | BRD4BRD2BRD3 | |
| 4-Hydroxy-Alprazolam SCHEMBL10891720 | 0.76 | BRD4 (0.60) | OPRK1GABRA1GABRA5GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |
| US-5807850-A | Therapeutic agent for osteoporosis and triazepine compound | JAPAN TOBACCO, INC. (JP) | 1998-09-15 | — | — | US | disclosed |
| EP-0792880-A1 | OSTEOPOROSIS REMEDY AND TRIAZEPINE COMPOUND | Japan Tobacco Inc. (JP) | 1997-09-03 | — | — | EP | disclosed |
| US-3991070-A | Process for preparing halo triazolo benzodiazepine | THE UPJOHN COMPANY (US) | 1976-11-09 | — | — | US | disclosed |