Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195792 | 0.91 | KDM4E (0.48) | CYP2C9KDM4EMEN1KMT2ALMNA | |
| SCHEMBL8322440 | 0.88 | CYP2C9 (0.38) | CYP2C9KDM4EMEN1KMT2ALMNA | |
| SCHEMBL8320504 | 0.84 | CYP2C9 (0.37) | CYP2C9KDM4EMEN1KMT2ALMNA | |
| SCHEMBL8438421 | 0.78 | LMNA (0.47) | CYP2C9KDM4EMEN1KMT2ALMNA | |
| SCHEMBL8323456 | 0.76 | TSHR (0.39) | CYP2C9KDM4EMEN1KMT2ALMNA | |
| SCHEMBL8438483 | 0.71 | TSHR (0.60) | CYP2C9KDM4EMEN1KMT2ALMNA | |
| SCHEMBL8323999 | 0.70 | ELANE (0.39) | CYP2C9KDM4EMEN1KMT2ACYP3A4 | |
| SCHEMBL8323687 | 0.70 | HPGD (0.55) | KDM4ELMNAHSD17B10TSHRALDH1A1 | |
| SCHEMBL11724014 | 0.69 | ACHE (0.47) | KDM4EKMT2AALDH1A1GAANPSR1 | |
| SCHEMBL8318492 | 0.67 | LMNA (0.44) | CYP2C9KDM4EMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717043-B1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1999-11-10 | — | — | EP | claimed |
| EP-0717043-A1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1996-06-19 | — | — | EP | claimed |