Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ST6GAL1 | P15907 | 3/20 | 0.60 |
| ▸ | ST3GAL1 | Q11201 | 2/20 | 0.60 |
| ▸ | ST3GAL3 | Q11203 | 2/20 | 0.60 |
| ▸ | FUT6 | P51993 | 1/20 | 0.51 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.33 |
| ▸ | SDCBP | O00560 | 2/20 | 0.33 |
| ▸ | SDC2 | P34741 | 2/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16406507 | 0.69 | ALOX15 (0.39) | MAPTALOX15SMN1; SMN2PTPN1LMNA | |
| SCHEMBL10081981 | 0.65 | NR1H4 (0.35) | MAPTALOX15SMN1; SMN2PTPN1SDCBP | |
| SCHEMBL2624832 | 0.62 | ALOX5 (0.33) | PTPN1 | |
| SCHEMBL825642 | 0.59 | MAPT (1.00) | MAPTALOX15SMN1; SMN2SDCBPSDC2 | |
| SCHEMBL4203635 | 0.59 | MAPT (1.00) | MAPTALOX15SMN1; SMN2SDCBPSDC2 | |
| SCHEMBL20014176 | 0.58 | MAPT (0.85) | MAPTALOX15SMN1; SMN2SDCBPSDC2 | |
| SCHEMBL24064895 | 0.57 | MAPT (0.74) | MAPTALOX15SMN1; SMN2SDCBPSDC2 | |
| SCHEMBL24064924 | 0.56 | MAPT (0.64) | MAPTALOX15SMN1; SMN2SDCBPSDC2 | |
| SCHEMBL12643502 | 0.55 | MAPT (0.74) | MAPTALOX15SMN1; SMN2SDCBPSDC2 | |
| SCHEMBL2181074 | 0.55 | MAPT (0.74) | MAPTALOX15SMN1; SMN2SDCBPSDC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572697-B1 | SPIROBENZOFURANLACTAM DERIVATIVES, METHODS FOR THEIR PREPARATION, AND USE THEREOF | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-02-21 | — | — | EP | disclosed |
| US-7160917-B2 | Spirobenzofuran lactams and their derivatives, processes for their preparation and use thereof | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-01-09 | — | — | US | disclosed |
| US-7160917-B2 | Spirobenzofuran lactams and their derivatives, processes for their preparation and use thereof | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-01-09 | — | — | US | disclosed |
| WO-2004055021-A1 | NOVEL SPIROBENZOFURANLACTAMS AND THE DERIVATIVES THEREOF, METHODS FOR THE PRODUCTION THEREOF, AND USE THEREOF | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-01 | — | — | WO | disclosed |