Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 8/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27354691 | 0.75 | HTR4 (0.33) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| Iodide SCHEMBL7399142 | 0.70 | HTR2C (0.37) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL2944408 | 0.61 | HTR4 (0.50) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL8465398 | 0.61 | HTR2C (0.37) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL5316403 | 0.59 | SMN1; SMN2 (0.44) | HTR4LMNA | |
| SCHEMBL2946654 | 0.59 | HTR4 (0.45) | HTR4HTR2CCYP2C9ADRA2CHTR1D | |
| SCHEMBL8319499 | 0.57 | HTR4 (0.61) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL7353994 | 0.55 | HTR4 (0.52) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL9053612 | 0.55 | KDM4E (0.42) | CYP3A4CYP2C9LMNATHRBNPSR1 | |
| SCHEMBL505507 | 0.54 | HTR4 (0.41) | HTR4HTR2CHTR3AHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604494-B1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-28 | — | — | EP | claimed |