Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324625 | 0.92 | HDAC1 (0.55) | RAB9AHDAC1HDAC8HDAC6LMNA | |
| SCHEMBL8323071 | 0.90 | HSP90AA1 (0.42) | HDAC1HDAC8HDAC6HSP90AA1ALDH1A1 | |
| SCHEMBL8320543 | 0.78 | HDAC3 (0.44) | RAB9AHDAC1HDAC8HDAC6LMNA | |
| SCHEMBL8319480 | 0.76 | HDAC1 (0.42) | RAB9AHDAC1HDAC8HDAC6HDAC3 | |
| SCHEMBL8319908 | 0.73 | HDAC1 (0.64) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8322757 | 0.72 | RNASEH1 (0.52) | RAB9AHDAC1HDAC8HDAC6LMNA | |
| SCHEMBL8320097 | 0.70 | HDAC1 (0.50) | RAB9AHDAC1HDAC8HDAC6LMNA | |
| SCHEMBL8325026 | 0.70 | HDAC3 (0.48) | RAB9AHDAC1HDAC8HDAC6LMNA | |
| SCHEMBL8320490 | 0.70 | HDAC1 (0.57) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8319616 | 0.70 | HDAC1 (0.57) | HDAC1HDAC8HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |