Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437322 | 0.77 | NPSR1 (0.49) | LMNASLC6A2SLC6A4SLC6A3TSHR | |
| SCHEMBL8321979 | 0.77 | CYP2C9 (0.38) | MAPTLMNATP53SLC6A3MEN1 | |
| SCHEMBL8318733 | 0.73 | HPGD (0.43) | LMNATSHRADRA2AADRA2BADRA2C | |
| SCHEMBL8438353 | 0.70 | NPSR1 (0.65) | LMNATP53SLC6A4SLC6A3TSHR | |
| SCHEMBL8195792 | 0.70 | KDM4E (0.48) | MAPTLMNATP53SLC6A3MEN1 | |
| SCHEMBL8321662 | 0.66 | KDM4E (0.38) | KCNH2MEN1KMT2ATSHRADRA2C | |
| SCHEMBL8320504 | 0.66 | CYP2C9 (0.37) | MAPTLMNATP53SLC6A3MEN1 | |
| SCHEMBL8441182 | 0.64 | NPSR1 (0.44) | LMNASLC6A2SLC6A4SLC6A3TSHR | |
| SCHEMBL8602746 | 0.63 | TSHR (0.58) | MAPTLMNAMEN1KMT2ATSHR | |
| SCHEMBL8438079 | 0.63 | NPSR1 (0.44) | LMNATSHRNPSR1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717043-B1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1999-11-10 | — | — | EP | claimed |
| EP-0717043-A1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1996-06-19 | — | — | EP | claimed |