Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326076 | 0.96 | HPGD (0.42) | HPGDNPSR1KDM4ESMN1; SMN2ABCC1 | |
| SCHEMBL8321662 | 0.84 | KDM4E (0.38) | HPGDKDM4EPOLBGAATSHR | |
| SCHEMBL8322440 | 0.78 | CYP2C9 (0.38) | HPGDNPSR1KDM4EGAATSHR | |
| SCHEMBL9217592 | 0.75 | NPSR1 (0.69) | HPGDNPSR1KDM4ESMN1; SMN2ABCC1 | |
| SCHEMBL8468645 | 0.73 | HPGD (0.43) | HPGDNPSR1KDM4ESMN1; SMN2POLB | |
| SCHEMBL8321061 | 0.73 | HPGD (0.41) | HPGDNPSR1KDM4ESMN1; SMN2POLB | |
| SCHEMBL8323999 | 0.71 | ELANE (0.39) | HPGDKDM4EPOLBGAATSHR | |
| SCHEMBL8319794 | 0.68 | POLB (0.47) | HPGDNPSR1KDM4EPOLBGAA | |
| SCHEMBL8562368 | 0.67 | HPGD (0.46) | HPGDNPSR1KDM4ESMN1; SMN2ABCC1 | |
| SCHEMBL9312804 | 0.67 | ABCC1 (0.65) | HPGDNPSR1KDM4ESMN1; SMN2ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717043-B1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1999-11-10 | — | — | EP | claimed |