Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 4/20 | 0.52 |
| ▸ | KDM4A | O75164 | 4/20 | 0.52 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.52 |
| ▸ | HIF1AN | Q9NWT6 | 4/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.52 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.52 |
| ▸ | KDM3B | Q7LBC6 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | BRS3 | P32247 | 3/20 | 0.47 |
| ▸ | PDE9A | O76083 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320061 | 0.87 | ALDH1A1 (0.53) | HTR1ADRD2ABCB1DAOPDE9A | |
| SCHEMBL8327202 | 0.82 | ALDH1A1 (0.55) | HTR1ADRD2PTGER1 | |
| SCHEMBL8326795 | 0.81 | HTR1A (0.54) | KDM6BKDM4AKDM4DHIF1ANKDM5B | |
| SCHEMBL8327188 | 0.81 | HTR1A (0.47) | HTR1ADRD2ABCB1DAOPDE9A | |
| SCHEMBL8321604 | 0.75 | HTR1A (0.49) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8677419 | 0.74 | HTR1A (0.54) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8674773 | 0.74 | HTR1A (0.60) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8320867 | 0.74 | ABCB1 (0.52) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8675205 | 0.73 | PTGER1 (0.71) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8675521 | 0.73 | PTGER1 (0.67) | HTR1ADRD2PTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |