Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18452554 | 0.93 | PDE4A (0.56) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL27810471 | 0.93 | PDE4A (0.56) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL4373395 | 0.86 | PDE4A (0.39) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| Adipic Acid SCHEMBL28621332 | 0.82 | PDE4A (0.48) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| Sebacic Acid SCHEMBL27941053 | 0.80 | PDE4A (0.47) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL6073282 | 0.80 | LMNA (0.37) | LMNA | |
| SCHEMBL5919108 | 0.79 | PDE4A (0.48) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL818364 | 0.79 | PDE4A (0.48) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL15948731 | 0.79 | PDE4A (0.48) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL29375023 | 0.79 | PDE4A (0.48) | PDE4ALMNAL3MBTL1TDP1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496617-B1 | Adenosine kinase inhibitors | METABASIS THERAPEUTICS INC (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5864033-A | ENZYME INHIBITORS WITH HETEROCYCLIC BASES | METABASIS THERAPEUTICS, INC. (US) | 1999-01-26 | — | — | US | disclosed |
| EP-0682519-A4 | ADENOSINE KINASE INHIBITORS. | GENSIA INC (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5646128-A | TREATING INFLAMMATION, SEPSIS, SEPTIC SHOCK, BURNS | GENSIA, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0682519-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1994017803-A9 | ADENOSINE KINASE INHIBITORS | — | 1994-09-29 | — | — | WO | disclosed |
| WO-1994017803-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| WO-1992012718-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1992-08-06 | — | — | WO | disclosed |
| EP-0496617-A1 | Adenosine kinase inhibitors | GENSIA, INC. (US) | 1992-07-29 | — | — | EP | disclosed |