Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 3/20 | 0.59 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.59 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.59 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325607 | 0.93 | PTGER1 (0.52) | PTGER4PTGER3PTGER2PTGER1HTR1A | |
| SCHEMBL8675829 | 0.89 | PTGER1 (0.71) | PTGER4PTGER3PTGER2PTGER1HTR1A | |
| SCHEMBL8322717 | 0.85 | PTGER1 (0.77) | PTGER4PTGER3PTGER2PTGER1HTR1A | |
| SCHEMBL9064386 | 0.83 | PTGER1 (0.73) | PTGER4PTGER3PTGER2PTGER1HTR1A | |
| SCHEMBL8327569 | 0.82 | PTGER1 (0.73) | PTGER4PTGER3PTGER2PTGER1HTR1A | |
| SCHEMBL8324233 | 0.82 | PTGER4 (0.61) | PTGER4PTGER3PTGER2PTGER1HTR1A | |
| SCHEMBL8676069 | 0.81 | PTGER1 (0.63) | PTGER4PTGER3PTGER2PTGER1HTR1A | |
| SCHEMBL8324992 | 0.81 | CCR5 (0.48) | PTGER1LMNARAB9AHPGD | |
| SCHEMBL7774976 | 0.81 | PTGER1 (0.59) | PTGER4PTGER3PTGER2PTGER1HTR1A | |
| SCHEMBL8327593 | 0.81 | PTGER4 (0.62) | PTGER4PTGER3PTGER2PTGER1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |