Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.52 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.52 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323253 | 0.93 | PTGER4 (0.59) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8676069 | 0.88 | PTGER1 (0.63) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8324992 | 0.87 | CCR5 (0.48) | PTGER1LMNARAB9AHPGD | |
| SCHEMBL8327306 | 0.85 | GCK (0.53) | PTGER1PTGER4PTGER3PTGER2LMNA | |
| SCHEMBL8326786 | 0.85 | PTGER1 (0.42) | PTGER1PTGER4PTGER3PTGER2LMNA | |
| SCHEMBL8406671 | 0.84 | HTR1A (0.66) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8675829 | 0.81 | PTGER1 (0.71) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8328278 | 0.81 | SMPD1 (0.56) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8325424 | 0.81 | ABCB1 (0.50) | HTR1ADRD2ABCB1LMNAKMT2A | |
| SCHEMBL8022247 | 0.81 | GABRA5 (0.52) | PTGER1PTGER4PTGER3PTGER2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |