SCHEMBL8323406

SCHEMBL8323406

CN1CC=C(c2c[nH]c3ccc(NCc4cccc5[nH]ccc45)nc23)CC1

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 7/20 0.50
KDM4E B2RXH2 1/20 0.50
LMNA P02545 1/20 0.50
POLB P06746 1/20 0.50
HTR1A P08908 1/20 0.50
ALOX15 P16050 1/20 0.50
HTR6 P50406 1/20 0.50
HSD17B10 Q99714 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
HTR1F P30939 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30909042 1.00 SLC6A4 (0.50) SLC6A4KDM4ELMNAPOLBHTR1A
SCHEMBL30908825 0.77 HTR1F (0.48) SLC6A4KDM4ELMNAPOLBHTR1A
SCHEMBL7007191 0.77 HTR1F (0.48) SLC6A4KDM4ELMNAPOLBHTR1A
SCHEMBL30909126 0.77 HTR1F (0.55) HTR1AHTR6HTR1F
SCHEMBL7005902 0.77 HTR1F (0.55) HTR1AHTR6HTR1F
SCHEMBL7012821 0.76 HTR1F (0.47) SLC6A4KDM4ELMNAPOLBHTR1A
SCHEMBL30908999 0.76 HTR1F (0.47) SLC6A4KDM4ELMNAPOLBHTR1A
SCHEMBL7014305 0.76 HTR1F (0.47) SLC6A4KDM4ELMNAPOLBHTR1A
SCHEMBL30908981 0.76 HTR1F (0.47) SLC6A4KDM4ELMNAPOLBHTR1A
SCHEMBL7013047 0.76 SLC6A4 (0.49) SLC6A4KDM4ELMNAPOLBHTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260125645-A1 METHODS AND PHARMACOLOGICAL AGENTS FOR INCREASING EXPANSION, ENGRAFTMENT OR IMMUNE OUTPUT OF HUMAN HEMATOPOIETIC STEM CELLS IN TRANSPLANTATION AND DISEASE SETTINGS VALORISATION HSJ LP (CA) 2026-05-07 US disclosed
EP-0916670-A2 Pyrrolo-(3,2-b) pyridines and their use as 5-HT1F agonists ELI LILLY AND COMPANY (US) 1999-05-19 EP disclosed
US-5905084-A 5-SUBSTITUTED-3-(PIPERIDIN-4-YL)- AND -3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)PYRROLO(3,2-B)PYRIDINES; SIDE EFFECT REDUCTION; NERVOUS SYTEM AND PSYCHOLOGICAL DISORDERS ELI LILLY AND COMPANY (US) 1999-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260125645-A1 METHODS AND PHARMACOLOGICAL AGENTS FOR INCREASING EXPANSION, ENGRAFTMENT OR IMMUNE OUTPUT OF HUMAN HEMATOPOIETIC STEM CELLS IN TRANSPLANTATION AND DISEASE SETTINGS HTR1F, HTR1A, HTR1D SLC6A4 299/4885KDM4E 3551/4885LMNA 4061/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.