SCHEMBL8323585

SCHEMBL8323585

c1ccc(COc2ccc3c(c2)CN(Cc2c[nH]c4ncccc24)CC3)cc1

nearest known ligand 0.69

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DRD4 P21917 5/20 0.69
DRD3 P35462 4/20 0.69
DRD2 P14416 3/20 0.69
HRH3 Q9Y5N1 5/20 0.51
CYP2D6 P10635 1/20 0.51
HRH1 P35367 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.50
HTR2A P28223 4/20 0.48
REV1 Q9UBZ9 1/20 0.48
CARM1 Q86X55 1/20 0.46
HTR7 P34969 3/20 0.46
HTR1A P08908 2/20 0.46
HTR6 P50406 2/20 0.46
MET P08581 1/20 0.46
OPRM1 P35372 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1388121 0.83 DRD4 (0.76) DRD4DRD3DRD2CYP2D6HTR2A
SCHEMBL1387913 0.82 DRD4 (1.00) DRD4DRD3DRD2CYP2D6HTR2A
SCHEMBL8319654 0.82 DRD4 (0.71) DRD4DRD3DRD2CYP2D6HTR2A
SCHEMBL8320806 0.81 DRD4 (0.66) DRD4DRD3DRD2CYP2D6HTR2A
SCHEMBL1388148 0.79 DRD4 (0.76) DRD4DRD3DRD2CYP2D6HTR2A
SCHEMBL5199191 0.79 DRD4 (0.76) DRD4DRD3DRD2CYP2D6HTR2A
SCHEMBL1388233 0.76 DRD4 (0.66) DRD4DRD3DRD2CYP2D6HTR2A
SCHEMBL8318271 0.75 DRD4 (0.69) DRD4DRD3DRD2CYP2D6HTR2A
SCHEMBL8858021 0.74 DRD4 (0.77) DRD4DRD3DRD2CYP2D6HTR2A
SCHEMBL3045956 0.74 REV1 (0.70) DRD4DRD3HRH3CYP2D6HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0687267-B1 PYRROLO-PYRIDINE DERIVATIVES AS LIGANDS OF DOPAMINE RECEPTOR MERCK SHARP & DOHME (GB) 1999-09-01 EP claimed
US-5700809-A Pyrrolo-pyridine derivatives MERCK SHARP & DOHME, LTD. (GB) 1997-12-23 US claimed
EP-0687267-A1 PYRROLO-PYRIDINE DERIVATIVES MERCK SHARP & DOHME LTD. (GB) 1995-12-20 EP claimed
EP-0687267-B1 PYRROLO-PYRIDINE DERIVATIVES AS LIGANDS OF DOPAMINE RECEPTOR MERCK SHARP & DOHME (GB) 1999-09-01 EP disclosed
US-5700809-A Pyrrolo-pyridine derivatives MERCK SHARP & DOHME, LTD. (GB) 1997-12-23 US disclosed
EP-0687267-A1 PYRROLO-PYRIDINE DERIVATIVES MERCK SHARP & DOHME LTD. (GB) 1995-12-20 EP disclosed
WO-1994020459-A2 PYRROLO-PYRIDINE DERIVATIVES AS DOPAMINE RECEPTOR LIGANDS MERCK SHARP & DOHME LIMITED (GB) 1994-09-15 WO disclosed