SCHEMBL1387913

SCHEMBL1387913

c1ccc2c(c1)CCN(Cc1c[nH]c3ncccc13)C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD4 P21917 8/20 1.00
DRD2 P14416 6/20 1.00
DRD3 P35462 6/20 1.00
LMNA P02545 4/20 0.60
KDM4E B2RXH2 2/20 0.60
MAPT P10636 2/20 0.60
ALOX12 P18054 2/20 0.60
HTT P42858 2/20 0.60
SMN1; SMN2 Q16637 2/20 0.60
NPSR1 Q6W5P4 2/20 0.60
TDP1 Q9NUW8 2/20 0.60
GAA P10253 1/20 0.60
OPRK1 P41145 1/20 0.60
MAPK1 P28482 3/20 0.57
ALOX15 P16050 2/20 0.57
NPC1 O15118 1/20 0.57
TP53 P04637 1/20 0.57
HSP90AA1 P07900 1/20 0.57
RAB9A P51151 1/20 0.57
HTR2A P28223 7/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1388121 0.87 DRD4 (0.76) DRD4DRD2DRD3LMNAKDM4E
SCHEMBL1388148 0.87 DRD4 (0.76) DRD4DRD2DRD3LMNAKDM4E
SCHEMBL1387980 0.84 DRD4 (0.71) DRD4DRD2DRD3LMNAKDM4E
SCHEMBL8319654 0.84 DRD4 (0.71) DRD4DRD2DRD3KDM4EMAPK1
SCHEMBL1388339 0.83 DRD4 (0.70) DRD4DRD2DRD3LMNAKDM4E
SCHEMBL8323585 0.82 DRD4 (0.69) DRD4DRD2DRD3HTR2AHTR7
SCHEMBL8318271 0.82 DRD4 (0.69) DRD4DRD2DRD3LMNAMAPK1
SCHEMBL1388233 0.80 DRD4 (0.66) DRD4DRD2DRD3LMNAKDM4E
SCHEMBL8320806 0.80 DRD4 (0.66) DRD4DRD2DRD3LMNAMAPK1
SCHEMBL8872038 0.80 DRD2 (0.72) DRD4DRD2DRD3LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0687267-B1 PYRROLO-PYRIDINE DERIVATIVES AS LIGANDS OF DOPAMINE RECEPTOR MERCK SHARP & DOHME (GB) 1999-09-01 EP claimed
US-5700809-A Pyrrolo-pyridine derivatives MERCK SHARP & DOHME, LTD. (GB) 1997-12-23 US claimed
JP-H09500357-A 1997-01-14 JP claimed
EP-0687267-A1 PYRROLO-PYRIDINE DERIVATIVES MERCK SHARP & DOHME LTD. (GB) 1995-12-20 EP claimed
WO-1994020459-A2 PYRROLO-PYRIDINE DERIVATIVES AS DOPAMINE RECEPTOR LIGANDS MERCK SHARP & DOHME LIMITED (GB) 1994-09-15 WO claimed
EP-0687267-B1 PYRROLO-PYRIDINE DERIVATIVES AS LIGANDS OF DOPAMINE RECEPTOR MERCK SHARP & DOHME (GB) 1999-09-01 EP disclosed
US-5700809-A Pyrrolo-pyridine derivatives MERCK SHARP & DOHME, LTD. (GB) 1997-12-23 US disclosed
WO-1994020459-A2 PYRROLO-PYRIDINE DERIVATIVES AS DOPAMINE RECEPTOR LIGANDS MERCK SHARP & DOHME LIMITED (GB) 1994-09-15 WO disclosed