SCHEMBL8323598

SCHEMBL8323598

CCOc1nc(C)cc2nc(S(=O)(=O)Nc3c(C(F)(F)F)nn(CC)c3C)nn12

nearest known ligand 0.43

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.34
LMNA P02545 1/20 0.34
HTT P42858 1/20 0.34
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8327312 0.91 SMN1; SMN2 (0.35) SMN1; SMN2LMNAHTTTSHR
SCHEMBL8323109 0.85 SMN1; SMN2 (0.36) SMN1; SMN2LMNAHTT
SCHEMBL8327069 0.83 SMN1; SMN2 (0.34) SMN1; SMN2LMNAHTTTSHR
SCHEMBL8327430 0.83 TSHR (0.34) TSHR
SCHEMBL8321555 0.80 SMN1; SMN2 (0.39) SMN1; SMN2LMNAHTTTSHR
SCHEMBL8322858 0.80 SMN1; SMN2 (0.38) SMN1; SMN2LMNAHTT
SCHEMBL8326284 0.75 SMN1; SMN2 (0.34) SMN1; SMN2LMNAHTT
SCHEMBL8881335 0.74 TSHR (0.37) LMNAHTTTSHR
SCHEMBL8015385 0.73 L3MBTL1 (0.34) SMN1; SMN2
SCHEMBL8882800 0.72 TSHR (0.32) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0789698-B1 N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES DOW AGROSCIENCES LLC (US) 1999-07-07 EP claimed
EP-0789698-A1 N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES DOWELANCO (US) 1997-08-20 EP claimed
WO-1997008172-A1 N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES DOWELANCO (US) 1997-03-06 WO claimed
EP-0789698-B1 N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES DOW AGROSCIENCES LLC (US) 1999-07-07 EP disclosed