Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 7/20 | 0.52 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | ATIC | P31939 | 3/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lometrexol SCHEMBL18530 | 0.83 | GART (0.78) | GARTATIC | |
| SCHEMBL8874134 | 0.76 | DHFR (0.56) | GARTDHFRATIC | |
| SCHEMBL7490675 | 0.76 | DHFR (0.56) | GARTDHFRATIC | |
| Hydrochloric Acid SCHEMBL8875657 | 0.75 | DHFR (0.55) | GARTDHFRATIC | |
| Hydrochloric Acid SCHEMBL7487428 | 0.75 | DHFR (0.55) | GARTDHFRATIC | |
| SCHEMBL18552515 | 0.74 | GART (0.66) | GARTDHFRATIC | |
| SCHEMBL1065450 | 0.70 | GART (0.62) | GARTATIC | |
| SCHEMBL7831766 | 0.70 | ATIC (0.51) | GARTATICTYMS | |
| Lometrexol SCHEMBL17520098 | 0.69 | GART (1.00) | GARTATIC | |
| Lometrexol SCHEMBL14365 | 0.69 | GART (1.00) | GARTATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0593286-B1 | Intermediates for preparing antifolate compounds and processes thereto | LILLY CO ELI (US) | 1999-12-15 | — | — | EP | disclosed |
| US-5969136-A | Cyclization for preparing antifolate compounds | ELI LILLY AND COMPANY (US) | 1999-10-19 | — | — | US | disclosed |
| US-5486614-A | Intermediates for preparing antifolate compounds | ELI LILLY AND COMPANY (US) | 1996-01-23 | — | — | US | disclosed |
| EP-0593286-A2 | Intermediates for preparing antifolate compounds and processes there to | ELI LILLY AND COMPANY (US) | 1994-04-20 | — | — | EP | disclosed |