Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | HBB | P68871 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 6/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9801811 | 0.93 | ALDH1A1 (0.46) | ALDH1A1CYP1A2MAPK1CYP3A4IDO1 | |
| SCHEMBL8325193 | 0.83 | ALDH1A1 (0.53) | ALDH1A1CYP1A2MAPK1CYP3A4IDO1 | |
| SCHEMBL8325573 | 0.75 | ALDH1A1 (0.55) | ALDH1A1CYP1A2MAPK1CYP3A4IDO1 | |
| SCHEMBL9804546 | 0.73 | NMT1 (0.48) | ALDH1A1CYP1A2MAPK1CYP3A4IDO1 | |
| SCHEMBL9801813 | 0.72 | ALDH1A1 (0.49) | ALDH1A1CYP1A2MAPK1CYP3A4IDO1 | |
| SCHEMBL2970846 | 0.71 | MAPK1 (0.48) | ALDH1A1CYP1A2MAPK1CYP3A4IDO1 | |
| SCHEMBL29059750 | 0.71 | ALDH1A1 (0.50) | ALDH1A1CYP1A2MAPK1CYP3A4IDO1 | |
| SCHEMBL10575357 | 0.70 | ALDH1A1 (0.47) | ALDH1A1CYP1A2MAPK1CYP3A4IDO1 | |
| SCHEMBL29059749 | 0.70 | ALDH1A1 (0.49) | ALDH1A1CYP1A2MAPK1CYP3A4IDO1 | |
| SCHEMBL9806456 | 0.70 | SMN1; SMN2 (0.47) | ALDH1A1CYP1A2MAPK1CYP3A4IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |