Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 3/20 | 0.40 |
| ▸ | EDNRA | P25101 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326276 | 0.94 | EDNRB (0.42) | HPGDHTTEDNRBEDNRAMEN1 | |
| SCHEMBL8326459 | 0.89 | EDNRB (0.41) | HPGDEDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8326870 | 0.87 | LMNA (0.40) | EDNRBEDNRAMEN1KMT2AMAPT | |
| SCHEMBL8321015 | 0.83 | EDNRA (0.45) | HTTEDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8326182 | 0.81 | EDNRB (0.45) | HPGDEDNRBEDNRAMEN1KMT2A | |
| SCHEMBL9407273 | 0.78 | MAPT (0.38) | HPGDHTTTP53EDNRBEDNRA | |
| SCHEMBL8323649 | 0.77 | EDNRA (0.55) | EDNRBEDNRA | |
| SCHEMBL7007654 | 0.77 | MCL1 (0.40) | HPGDEDNRBEDNRAMEN1KMT2A | |
| SCHEMBL7009283 | 0.77 | EDNRB (0.40) | HPGDHTTEDNRBEDNRAMEN1 | |
| SCHEMBL7011111 | 0.75 | EDNRB (0.39) | HPGDEDNRBEDNRAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | claimed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | claimed |
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |