Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 11/20 | 0.48 |
| ▸ | CDK2 | P24941 | 11/20 | 0.48 |
| ▸ | EIF2AK2 | P19525 | 6/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325329 | 0.88 | CDK4 (0.50) | CDK4CDK2EIF2AK2 | |
| SCHEMBL8316906 | 0.83 | CDK4 (0.58) | CDK4CDK2EIF2AK2 | |
| SCHEMBL8324821 | 0.81 | CDK2 (0.44) | CDK4CDK2PDPK1 | |
| SCHEMBL8324834 | 0.79 | CDK4 (0.56) | CDK4CDK2EIF2AK2 | |
| SCHEMBL8317411 | 0.79 | CDK2 (0.58) | CDK4CDK2 | |
| SCHEMBL8324838 | 0.79 | EIF2AK2 (0.60) | CDK4CDK2EIF2AK2 | |
| SCHEMBL8325838 | 0.78 | CDK2 (0.49) | CDK4CDK2EIF2AK2 | |
| SCHEMBL8324386 | 0.78 | CDK2 (0.52) | CDK4CDK2EIF2AK2 | |
| SCHEMBL14011226 | 0.76 | SYK (0.51) | CDK4CDK2EIF2AK2 | |
| SCHEMBL4424686 | 0.75 | CDK4 (0.48) | CDK4CDK2EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456190-B2 | Compositions useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456190-B2 | Compositions useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-25 | — | — | US | disclosed |
| WO-2004083203-A1 | COMPOSITIONS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-09-30 | — | — | WO | disclosed |