Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.50 |
| ▸ | CDK2 | P24941 | 9/20 | 0.50 |
| ▸ | EIF2AK2 | P19525 | 7/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323685 | 0.88 | CDK4 (0.48) | CDK4CDK2EIF2AK2 | |
| SCHEMBL8316906 | 0.86 | CDK4 (0.58) | CDK4CDK2EIF2AK2JAK2 | |
| SCHEMBL8324821 | 0.84 | CDK2 (0.44) | CDK4CDK2JAK2MAPK13MAPK9 | |
| SCHEMBL8324834 | 0.82 | CDK4 (0.56) | CDK4CDK2EIF2AK2 | |
| SCHEMBL8324838 | 0.81 | EIF2AK2 (0.60) | CDK4CDK2EIF2AK2 | |
| SCHEMBL8317411 | 0.81 | CDK2 (0.58) | CDK4CDK2 | |
| SCHEMBL8324386 | 0.81 | CDK2 (0.52) | CDK4CDK2EIF2AK2JAK2MAPK13 | |
| SCHEMBL8325838 | 0.77 | CDK2 (0.49) | CDK4CDK2EIF2AK2JAK2MAPK13 | |
| SCHEMBL14011226 | 0.77 | SYK (0.51) | CDK4CDK2EIF2AK2 | |
| SCHEMBL4424686 | 0.73 | CDK4 (0.48) | CDK4CDK2EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456190-B2 | Compositions useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456190-B2 | Compositions useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-25 | — | — | US | disclosed |
| WO-2004083203-A1 | COMPOSITIONS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-09-30 | — | — | WO | disclosed |