Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 5/20 | 0.60 |
| ▸ | CDK2 | P24941 | 8/20 | 0.51 |
| ▸ | CDK4 | P11802 | 7/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | BCR | P11274 | 2/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316906 | 0.89 | CDK4 (0.58) | EIF2AK2CDK2CDK4CAMK2D | |
| SCHEMBL8324386 | 0.88 | CDK2 (0.52) | EIF2AK2CDK2CDK4CAMK2DABL1 | |
| SCHEMBL8324791 | 0.88 | EIF2AK2 (0.61) | EIF2AK2CDK2CDK4CAMK2DABL1 | |
| SCHEMBL8325838 | 0.85 | CDK2 (0.49) | EIF2AK2CDK2CDK4CAMK2DABL1 | |
| SCHEMBL8324834 | 0.84 | CDK4 (0.56) | EIF2AK2CDK2CDK4 | |
| SCHEMBL14011226 | 0.84 | SYK (0.51) | EIF2AK2CDK2CDK4 | |
| SCHEMBL8325329 | 0.81 | CDK4 (0.50) | EIF2AK2CDK2CDK4 | |
| SCHEMBL8317411 | 0.80 | CDK2 (0.58) | CDK2CDK4 | |
| SCHEMBL8323685 | 0.79 | CDK4 (0.48) | EIF2AK2CDK2CDK4 | |
| SCHEMBL8320329 | 0.78 | EIF2AK2 (0.58) | EIF2AK2CDK2CDK4CAMK2DABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456190-B2 | Compositions useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456190-B2 | Compositions useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-25 | — | — | US | disclosed |
| WO-2004083203-A1 | COMPOSITIONS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-09-30 | — | — | WO | disclosed |