Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3062312 | 0.91 | HTR6 (0.40) | HTR6HPGDKMT2ASMN1; SMN2KHK | |
| Hydrochloric Acid SCHEMBL3556265 | 0.89 | HPGD (0.39) | HTR6HPGDKMT2ASMN1; SMN2KHK | |
| SCHEMBL25508831 | 0.87 | HTR6 (0.38) | HTR6HPGDKMT2ASMN1; SMN2KHK | |
| SCHEMBL3996939 | 0.82 | HTR6 (0.47) | HTR6CXCR4HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL18136222 | 0.79 | — | — | |
| SCHEMBL12038515 | 0.79 | ALDH1A1 (0.35) | HTR6KMT2A | |
| SCHEMBL64117 | 0.78 | HTR6 (0.56) | HTR6CXCR4HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL2904654 | 0.78 | HTR6 (0.56) | HTR6CXCR4HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL6971805 | 0.78 | HTR6 (0.47) | HTR6HPGDKMT2ASMN1; SMN2KHK | |
| SCHEMBL13791869 | 0.77 | FYN (0.35) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737153-B2 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-15 | — | — | US | disclosed |
| US-7737153-B2 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-15 | — | — | US | disclosed |
| WO-2004039796-A1 | HETEROARYLOXY-SUBSTITUTED PHENYLAMINOPYRIMIDINES AS RHO-KINASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2004-05-13 | — | — | WO | disclosed |