Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.62 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.62 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.62 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | AR | P10275 | 4/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323878 | 0.89 | PKM (0.51) | PTGER1PTGER4PTGER3PTGER2MEN1 | |
| SCHEMBL8676578 | 0.87 | MEN1 (0.52) | PTGER1PTGER4PTGER3PTGER2MEN1 | |
| SCHEMBL8323803 | 0.83 | PTGER1 (0.51) | PTGER1PTGER4PTGER3PTGER2MEN1 | |
| SCHEMBL8459732 | 0.82 | PTGER1 (0.66) | PTGER1PTGER4PTGER3PTGER2MEN1 | |
| SCHEMBL8320717 | 0.81 | PTGER1 (0.77) | PTGER1PTGER4PTGER3PTGER2MEN1 | |
| SCHEMBL8320298 | 0.80 | MEN1 (0.51) | PTGER1PTGER4PTGER3PTGER2MEN1 | |
| SCHEMBL8319623 | 0.79 | PTGER1 (0.73) | PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8319420 | 0.78 | PTGER1 (1.00) | PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8322261 | 0.77 | PTGER1 (0.70) | PTGER1PTGER4PTGER3PTGER2MEN1 | |
| SCHEMBL3563796 | 0.76 | HDAC1 (0.66) | MEN1KMT2APOLBHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |